Identifiers
HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10
mitogen-activated protein kinase 8
HUGO:MAPK8 hgnc_id:HGNC:6881 HGNC:6881 ENTREZ:5599 UNIPROT:P45983
DSN1 homolog, MIS12 kinetochore complex component
HUGO:DSN1 hgnc_id:HGNC:16165 HGNC:16165 ENTREZ:79980 UNIPROT:Q9H410
mitogen-activated protein kinase 9
HUGO:MAPK9 hgnc_id:HGNC:6886 HGNC:6886 ENTREZ:5601 UNIPROT:P45984
mitogen-activated protein kinase 10
HUGO:MAPK10 hgnc_id:HGNC:6872 HGNC:6872 ENTREZ:5602 UNIPROT:P53779
HUGO:MAPK8 HUGO:MAPK9 HUGO:MAPK10
JNK1
HUGO:MAPK8 HGNC:6881, ENTREZ:5599, UNIPROT:P45983
JNK2
HUGO:MAPK9 HGNC:6886, ENTREZ:5601, UNIPROT:P45984
JNK3
HUGO:MAPK10 HGNC:6872, ENTREZ:5602, UNIPROT:P53779
JNK1, mitogen-activated protein kinase 8
JNK2, mitogen-activated protein kinase 9
JNK3, mitogen-activated protein kinase 10
PRKM8
PRKM9
PRKM10
HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8
HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9
HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_M_CHECKPOINT
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / RCD_GENES
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_NON_CANONICAL
References
PMID:10849438 PMID:11371360 PMID:8205621
REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8
mitogen-activated protein kinase 9
REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9
mitogen-activated protein kinase 10
REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10
CADCADE:TNF
CASCADE:IL1
CASCADE:PDGFB
PMID:15653932
TNF signaling activates ERK,JNK and p38 kinases in fibroblasts and induses TGFB expression
via ERK
PMID:26921338
PDGFB inhibits PEDF expression via p38 and JNK
PMID:21438496, PMID:21372320, PMID:19591900, PMID:17496919, PMID:15611655, PMID:8608010, PMID:20512932, PMID:20220133, PMID:20054826,
PMID:19616017
synonym:JNK1
synonym:JNK2
synonym:JNK3
MACROPHAGE
NATURAL_KILLER
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:IL18
CASCADE:NKG2D
CASCADE:TNF
CASCADE:IFNG
PMID:18287025
JNK is localized to the centrosome.
JNK induces assosiation of Paxilin with MTOC resulted in polarization of the MTOC
and cytolytic granules, and finally exocytosis of cytolytic proteins downstream of NKG2D.
Inhibition of JNK activity by D-JNK-1, SP600125, Or JNK-1-specific siRNA blocked polarization of granzyme B,
PMID:17070508
IL-2/IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun N-terminal kinase (JNK) pathway.
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-??B
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.
PMID:17379190
MEK4/JNK/AP-1 path way is active in mactophages downstream of TLR4,
and induces iNOS expression.
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:17073741
DUSP1 inhibits p38 and JNK pathways of innate innunity downstream of IL10.
PMID:9743347
IL13 inhibits JNK phosphorylation and AP1 activation (provavly via dusp1)
PMID:23681101, PMID:11477091
There are three main signaling pathways could be activated downstream of TRR4/MyD88/TAK1 signaling??: p38 (via MKK3 or MKK6), JNK (via MKK4 or MKK7) and NfkB ) IN DC all these signaling pathways are activated downstream of TLR4 and TLR2 signaling )
PMID:23508573
HMGB1 induces activation (phosphorylation) of ERK, JNK and p38 via TLR4 in macrophages.
PMID:11438547, PMID:24378531
in macrophages
Both TNFR1 and TNFR2 signaling pathways induce classical NFkB activation via IKBa degradation.
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling
References
PMID:16713974
TLR2 activates (induses phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
in_re929( Innate Immunity ):
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
References
in_re929( Innate Immunity ):
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
in_re1149( Innate Immunity ):
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
→ GZMB@default
→ AP1*|pho|active@INNATE_IMMUNE_CELL_Cytosol
+ PXN@INNATE_IMMUNE_CELL_Cytosol → PXN:TUBGCP2:TUBGCP3:TUBGCP4:TUBGCP5:TUBGCP6:Tubulin-_alpha_*:Tubulin-_beta_*:Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol