Reaction state_transition in_re929 map

JNK*@INNATE_IMMUNE_CELL_Cytosol map → JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
  2. MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
Inhibition
  1. DUSP1@INNATE_IMMUNE_CELL_Cytosol map
  2. IRF4@INNATE_IMMUNE_CELL_Cytosol map
  3. IFNG|​hm2@default map


References
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.