Protein CSF2 map

Identifiers
HUGO:CSF2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION  map

References
 NATURAL_KILLER  map
CASCADE:NKG2D
CASCADE:KIR2DS2
CASCADE:Fc_gamma_RIII
CASCADE:CSF2
PMID:11777960
ULBP2 induces SCF2 (GM-CSF), CLL4 (MIP1B) and IFNG secretion via PI3K pathway via NKG2D.
PMID:11015446
Cross-linking of the KIR2DS2/DAP12 receptor on NKL cells resulted in the dose-dependent secretion of IFNG and GM-CSF
PMID:21765015, PMID:22869907
CSF2 signaling can have both positive and negative influence on angiogenesis in tumors.
First, CSF2 upregulates angiogenic factor VEGF expression via HIF1a, specific inhibition of PHD2 increases VEGF production. Second, CSF2 upregulates expression of soluble form of VEGFR (sVEGFR-1) wich inhibits VEGF signaling via HIF2a. (
PMID:24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-??.
PMID:20805416
In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF
And this signaling is needful for DC differentiation.

CSF2@default

References
in_re163( Innate Immunity  map ):
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.
in_re429( Innate Immunity  map ):
PMID:12907458, PMID:12193690
IL10 upregulates expression
of IL4RA in STAT3 dependent manner.
in_re884( Innate Immunity  map ):
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.
PMID:11280761
VEGF signaling blocs TNF-?? induced activation of I??B kinase (IKK complex).This decreased IKK activation correlated with the inhibition of I??B?? phosphorylation and degradation of I??B?? and I??B?? in HPCs, and this inhibition is inhdependent or FLT1 and KDR
in_re1088( Innate Immunity  map ):
PMID:12907458
IL10 induces SOCS3 expression in STAT3 dependent manner.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CSF2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CSF2@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CSF2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2@default map
  2. CSF2@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
  3. rCSF2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2@INNATE_IMMUNE_CELL_Cytosol map
  4. CSF2@default map + CSF2RA:​CSF2RB@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
  2. CXCL1@INNATE_IMMUNE_CELL_Cytosol map → map CXCL1@default map
  3. IL8*@INNATE_IMMUNE_CELL_Cytosol map → map IL8*@default map
  4. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  5. gIL4R@INNATE_IMMUNE_CELL_Cytosol map → map rIL4R@INNATE_IMMUNE_CELL_Cytosol map
  6. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  8. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  9. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  10. gIRF5@INNATE_IMMUNE_CELL_Cytosol map → map rIRF5@INNATE_IMMUNE_CELL_Cytosol map
  11. HIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map HIF2A*@INNATE_IMMUNE_CELL_Cytosol map
  12. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map HIF1A@INNATE_IMMUNE_CELL_Cytosol map