Complex CSF2:CSF2RA:CSF2RB:JAK2 map
Complex composition:

  1. CSF2RB map
  2. CSF2RA map
  3. CSF2 map
  4. JAK2 map

CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:CSF2:CSF2RA:CSF2RB:JAK2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:12393492
CSF2 acts via heterodimer receptor contains CSF2RA and SSF2RB subunits
in_re707( Innate Immunity  map ):
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CSF2@default map + CSF2RA:​CSF2RB@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map