Protein STAT5* map

Identifiers
signal transducer and activator of transcription 5A
HUGO:STAT5A HGNC:11366 ENTREZ:6776 UNIPROT:P42229
signal transducer and activator of transcription 5B
HUGO:STAT5B HGNC:11367 ENTREZ:6777 UNIPROT:P51692
HUGO:STAT5A HUGO:STAT5B

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / RCD_GENES  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:28186502
 MACROPHAGE  map
 MDSC  map
 NATURAL_KILLER  map
CASCADE:IL15
CASCADE:IL21
CASCADE:IL2
CASCADE:CSF2
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.
PMID:24091328
G-CSF downregulates IRF8 expression via STAT3 and GM-CSF via STAT5. IRF8 inhibition provides immunosuppressive functions of MDSC.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.)

STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol

References
in_re714( Innate Immunity  map ):
PMID:11964313
INFG upregulates expression components of TLR signaling: MD2 (LY96) and MYD88.
in_re717( Innate Immunity  map ):
PMID:12433365
INFG induces SOCS1 expression in macrophages.
PMID:10820262
Probably IFNG induces SOCS1 expressiov via IRF1 upregulation downstream of STAT1
PMID:18345002
TNF induces IRF1 expression both through TNFR1 and TNFR2.
TNF induced IFNB expression through IRF1

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STAT5*@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. ICAM1@INNATE_IMMUNE_CELL_Cytosol map → map ICAM1@INNATE_IMMUNE_CELL_Membrane map
    2. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
    3. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
    4. CD86@INNATE_IMMUNE_CELL_Cytosol map → map CD86@INNATE_IMMUNE_CELL_Membrane map
    5. gCIITA@INNATE_IMMUNE_CELL_Cytosol map → map rCIITA@INNATE_IMMUNE_CELL_Cytosol map
    6. gMYD88@INNATE_IMMUNE_CELL_Cytosol map → map rMYD88@INNATE_IMMUNE_CELL_Cytosol map
    7. gIRF1@INNATE_IMMUNE_CELL_Cytosol map → map rIRF1@INNATE_IMMUNE_CELL_Cytosol map
    8. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
    9. gIL2RA@INNATE_IMMUNE_CELL_Cytosol map → map rIL2RA@INNATE_IMMUNE_CELL_Cytosol map
    10. gIRF8@INNATE_IMMUNE_CELL_Cytosol map → map rIRF8@INNATE_IMMUNE_CELL_Cytosol map
    11. gPRF1@INNATE_IMMUNE_CELL_Cytosol map → map rPRF1@INNATE_IMMUNE_CELL_Cytosol map