Identifiers
HUGO:CIITA
References
DENDRITIC_CELL
MACROPHAGE
CASCADE:IL4
CASCADE:CSF2
CASCADE:IFNG
PMID:??19224634
STAT5 promotes expression of MHC class II transactivator protein (CIITA) and upregulates MHC class II expression downstream of CSF2 (
PMID:16785500
ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages
downstream of TLR4 MyD88-dependent signaling.
PMID:11514596
Maturation of Dendritic Cells Is Accompanied by Rapid Transcriptional Silencing of Class II Transactivator (Ciita) Expression and
down regulation of MHCII expression. ERK and p38 MAPK suppress CIITA expression by decreasing histone acetylation
PMID:20580461
In macrophages IRF4 upregulates expression of CIITA, CYP1B1, CCL24, MPP6, and downregulate expression IL1RN downstream of IL4.
PMID:??8624807
IFN-?? has been shown to up-regulate MHC class II expression on dendritic cells.??
Probably via CIITA.
PMID:11983150
IFNG signaling induces CIITA expression in Dcs probably via IRF-1, IRF-2, and STAT1 binding to CIITA gene promoter.