Protein CYTH1 map

Identifiers
HUGO:CYTH1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
PMID:11050434
The cytohesin and centaurin protein families are potential targets for PtdIns(3,4,5)P3 that also regulate and interact with Arf GTPases.
PMID:1511013, PMID:10652308
Cytohesin-1 (B2-1) found at high levels in natural killer and cytotoxic T-cells and at very low levels in monocytes and several cultured cell lines.
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes.
Cytohesin-1 can activate ARF6

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CYTH1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CYTH1@INNATE_IMMUNE_CELL_Cytosol map → map CYTH1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. ARF6:​GDP@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map ARF6:​GTP@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map