Identifiers
HUGO:PSD4
References
DENDRITIC_CELL
PMID:21458045
PSD4 is selectively expressed in the immune system and promotes GTP loading of ARL14/ARF7.
Probably downstream of PIP5K1A.
Identifiers
HUGO:STAT3
References
PMID:???21115385, PMID:7543512
???The binding of IL-10 to its receptor activates JAK1
Two tyrosines??? (???Tyr??? ???446??? ???and Tyr??? ???496???) ???of IL-10RA
are phosphorylated by the JAK1,??? ???to which
the transcription factor STAT3??? ???binds via its SH2??? ???domain
and in turn becomes itself phosphorylated.
PMID:10347215
Only JAK1/STAT3 pathway (but not TYK) plays role in
anti-inflammatory action of IL10 in macrophages.