Identifiers
HUGO:SOS1 HUGO:SOS2
HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2
SOS Ras/Rac guanine nucleotide exchange factor 1
HUGO:SOS1 hgnc_id:HGNC:11187 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889
SOS Ras/Rho guanine nucleotide exchange factor 2
HUGO:SOS2 hgnc_id:HGNC:11188 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890
son of sevenless homolog 1 (Drosophila)
HUGO:SOS1, HGNC:11187, ENTREZ:6654, UNIPROT:Q07889 , GENECARDS:GC02M039208
son of sevenless homolog 2 (Drosophila)
HUGO:SOS2, HGNC:11188, ENTREZ:6655, UNIPROT:Q07890, GENECARDS:GC14M050583
GINGF "gingival fibromatosis hereditary 1"
HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889
"son of sevenless (Drosophilia) homolog 2"
HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890
HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1
HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
References
PMID:16102570 PMID:7510700 PMID:24027568
CASCADE:FGF
CASCADE:EGFR
GASCADE:IGF1R
PMID:15863030
GRB2 forms a complex with SOS protein and activate it downstream of FGF signaling
PMID:10567412; PMID:15567848
EGFR activates ERK via GRB2/SOS/RAS/RAF pathway
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos
SOS is an GTP-exchange factor for Ras
son of sevenless homolog 1 (Drosophila)
REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1
son of sevenless homolog 2 (Drosophila)
REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2
GINGF "gingival fibromatosis hereditary 1"
"son of sevenless (Drosophilia) homolog 2"
NATURAL_KILLER
CASCADE:Fc_gamma_RIII
PMID:8551221
CD16 and IL-2R Triggering Activate p21RAS in Human NK Cells via LAT/SHC/GRB2/sos pathway.
Phosphorylated Shc interacts with Grb2, which, in turn, interacts with Sos.
Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state.
PMID:17496910
PMID:15574420
PMID:11777939