Protein GAB2 map

Identifiers
HUGO:GAB2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:11572860 PMID:12640133
 MAST_CELL  map
 NATURAL_KILLER  map
PMID:16212621, PMID:10982827
Phosphorylation of Gab2 was enhanced by both IL-2 and IL-15 in T cells.
IL-2- and IL-15-induced Gab2-PI3K association and downstream AKT activation in T cells and B cells.
PMID:10849428
IL-2 but not IL-4, IL-12, or IFN-??/??, was able to induce the phosphorylation of Gab2 in NK cells
and induces its association with PI3K (p85).
JAK3 probably plays a pivotal role for in IL-2-dependent Gab2 phosphorylation.
PMID:19909365
GAB2 lthough it has been long recognized that PI3K signaling is important for the regulation of
Fc??RI-mediated activation of MCs (161???163), the molecular link between Fc??RI and
activation of PI3K

GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol

References
in_re163( Innate Immunity  map ):
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GAB2@INNATE_IMMUNE_CELL_Cytosol map
  2. GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GAB2@INNATE_IMMUNE_CELL_Cytosol map → map GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map