Identifiers
NAME:GRB2:SHC1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
NATURAL_KILLER
MAST_CELL
CASCADE:Fc_gamma_RIII
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:16212621, PMID:10849428
IL-2- and IL-15-induced phosphorylation of the adapter protein Shc and Shc/Grb2 coupling in NK cells and T cells.
PMID:10982827
Shc and GRB2 mediate Gab2 tyrosyl phosphorylation. Mutation of the three tyrosyl phosphorylation sites of Shc, which bind Grb2, blocks the ability of the Shc chimera to evoke Gab2 tyrosyl phosphorylation in B cells.
PMID:8551221, PMID:10358164
SHC1 protein is phosphorylated upon CD16 and IL-2R Stimulation in Human NK Cells and interacts with GRB2.
CD16 and IL-2R Triggering Activate p21RAS in Human NK Cells via LAT/SHC/GRB2/sos pathway.
Phosphorylated Shc interacts with Grb2, which, in turn, interacts with Sos.
PMID:9763606
Cross-linking of ??1 Integrins on Human NK Cells Induces Shc Tyrosine Phosphorylation and Grb2 Association via Pyk-2end
resulted in RAS/ERK activation.
PMID:19909365
MAST cells