Complex SHC1:SHIP1* map
Complex composition:

  1. SHIP1* map
  2. SHC1 map

SHC1|​pho:​SHIP1*|​pho@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:SHC1:SHIP1*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
PMID:11449354, PMID:12393695
CD16 cross-linking on human NK cells induces the association of SHIP-1 with receptor zeta-chain through the adaptor protein shc.
Fc gamma RIII alpha (CD16) autoregulates activation of downstream signals trough CD3 zeta/ Shc/ Inositol polyphosphate-5-phosphatase 145kDa ( SHIP ) pathway. The hypothetical mechanism consists of SHIP participation in inhibition of Ca('2+) -depend pathway and signal from PI3K via decreased amount IP3 [45] and PtdIns(3,4,5)P3.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SHC1|​pho:​SHIP1*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SHIP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map SHC1|​pho:​SHIP1*|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. PIP3*@INNATE_IMMUNE_CELL_Cytosol map → map PIP2*@INNATE_IMMUNE_CELL_Cytosol map