Protein PTPN6 map

Identifiers
HUGO:PTPN6
protein tyrosine phosphatase, non-receptor type 6
HUGO:PTPN6 hgnc_id:HGNC:9658 HGNC:9658 ENTREZ:5777 UNIPROT:P29350
HUGO:PTN6

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / CORE  map
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map

References
PMID:15240681
PMID:27474009; PMID:26667266
STAT3 acetylation and phosphorylation are inversely correlated with SHP-1 expression.
CASCADE:FCGR2B
CASCADE:KIR2DL3
CASCADE:KIR2DL2
CASCADE:KIR2DL1
CASCADE:NKG2A
CASCADE:KIR3DL1
CASCADE:2B4
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:25355530, PMID:12917349, PMID:22952938, PMID:22513334
SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells.
Gene silencing of the SHP-1 in primary NK cells abrogated the ability of ITIM-containing NK inhibitory receptors to suppress the activation signals induced by NK1.1 activating receptors.
Vav1 dephosphorylation by the tyrosine phosphatase PTPN-6 (SHP-1) as a mechanism for inhibition.
of cellular cytotoxicity downstream of KIR-receptor (KIR2DL1).
Additionally probably activated SHP-1 binds to Lck (through the Lck SH2 domain), which leads to dephosphorylation and inactivation of Lck by SHP-1 (demonstrated in T cells).
PMID:8976179
PTP-1C (SHP-1) binds to and dephosphorylates pp36 (LAT) and disrupted the ability of pp36 (LAT) to associate with Grb2 downstream of KIR3DL1in NK cells.
PMID:9765283
SHP-1 can bind and dephosphorylate LCP2 (SLP-76) in NK cells downstream of KIRs
PMID:8986721
SHP-1 participates in ZAP-70, PLC-G dephosphorylation (inactivation) downstream of KIRs.
PMID:15713798
The phosphorylated third ITSM of 2B4 can recruit the phosphatases SHP-1, SHP-2, SHIP, and the inhibitory kinase Csk. SAP acts as an inhibitor of interactions between 2B4 and these negative regulatory molecules, explaining how 2B4 inhibits NK-cell activation in the absence of functional SAP.
PMID:12176909, PMID:12773515
In macrophages SHP-1 inhibits Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Probably downstream of FcgammaRII(b) and other receptors.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTPN6@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map VAV1@INNATE_IMMUNE_CELL_Cytosol map