IL6

Protein IL6

Identifiers
HUGO:IL6
interleukin 6
HUGO:IL6 hgnc_id:HGNC:6018 HGNC:6018 ENTREZ:3569 UNIPROT:P05231

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / INFLAMMATORY_SIGNALING_PATHWAYS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:27557510
CASCADE:TGFB
CASCADE:PGE
CASCADE:IL1
PMID:23034983
TGFB upregulates gene expression of CAF markers ,??FSP1 (S100A4), and??TNC. (provably via SMAD3), and gene expression of CCL5, SDF1(CXCL12), BMP4, IL6, CXCL7, IL6R, IL6ST, CXCL5
PMID:26268945
Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration
PMID:24346288
Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.
IL-6 enhanced VEGF production by fibroblasts, thereby inducing angiogenesis.
PMID:20138012
PTGS2, CXCL1, and CXCL2; the proinflammatory cytokines IL-1?? and IL-6, CYR61 and OPN are upregulated in CAFs,
probably downstream of IL1B via NFkB
PMID:19581928; PMID:24011634
Interleukin-6 induces an epithelial???mesenchymal transition phenotype in human breast cancer cells
PMID:24011634
Lung-derived fibroblasts were activated by IL-6 and TGF-??
IL-6 enhanced TGF-?? signaling in A549 cells and lung-derived fibroblasts probably via increased expression of TGF-?? receptor type I on the cell surface.
PMID:26201938
The expression levels of cytokine genes, including those for IL6, CXCL8, TNF, TGFB1, and VEGFA, were higher in CAFs. T cell proliferation was suppressed more by CAFs or their supernatants than by NFs.
PMID:23567181
Tumor necrosis factor (TNF) and IL6 were shown to be a potent mast cell chemoattractant. TNF induced a strong, dose-dependent migratory response of peritoneal mast cells
PMID:25002027
SQSTM1 (p62) p62 is a suppressor of inflammation and the CAF phenotype in the tumor microenvironment
p62 controls IL-6 levels by repressing ROS production through metabolic reprogramming
PMID:18209571
Roles of MAPK and NF-_kappa_B in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.
PMID:18555778
In response to oncogenic stress, both IL6 and IL8 genes were activatedbythe transcription factorC/EBPb,upon its recruitment to either promoter.PMID:18555778
PMID:18555777
There is a positive feedback loop between IL6 and CEBP that help maintain the senescence state
MACROPHAGE
DENDRITIC_CELL
MAST_CELL
CASCADE:IL6
CASCADE:TLR2_4
CASCADE:STING
CASCADE:FCAR
CASCADE:IL15
PMID:7590867
Fc alpha receptors mediate release of tumour necrosis factor-alpha and interleukin-6 by human monocytes following receptor aggregation
PMID:15573129, PMID:8837607, PMID:9845545
Macrophage colony-stimulating factor (M-CSF) and IL-6 have also been reported to be involved in the tumour-mediated regulation of DC differentiation.
PMID:15356132
The activation of STAT3 by IL-6 was required for the suppression of LPS-induced DC maturation. In addition, STAT3 was required for the IL-6-mediated suppression of bone-marrow-derived DC activation and/or maturation
PMID:11306493
The presence of high (>400 pg/ml) concentrations of IL-6 and M-CSF in tumor cell supernatant was strongly correlated with the inhibitory capacity of tumor cell medium on MO-DC differentiation
PMID:25582338
mIL-15 DCs secreted markedly greater amounts of proinflammatory cytokines, including IL-1??, IL-1??, IL-6, TNF??, TNF?? and IFN-??, compared with mIL-4 DCs, suggesting that mIL-15 DCs are more proinflammatory than mIL-4 DCs.
The IFN-??, TNF?? and IL-6 transcripts were consistently expressed at higher levels at 330-, 14- and 20-folds, respectively, in donor-matched mIL-15 DCs than mIL-4 DCs
16286017??
IL-6-STAT3 Controls Intracellular MHC Class II ???? Dimer Level through Cathepsin S Activity in Dendritic Cells. IL-6 Stimulation via STAT3 Decreased Cystatin C Expression, Increased the Cathepsin S Activity, and Reduced the MHCII ???? Dimer Level in DCs In Vivo
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18

IL6@INNATE_IMMUNE_CELL_Cytosol

References
in_re557( Innate Immunity ):
PMID:20547845, PMID:10952726
TLR4 signaling downstream of HMGB1 induces secretion of IL6 probably via NFkB

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

IL6@INNATE_IMMUNE_CELL_Cytosol

In compartment: default

IL6@default

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: