Identifiers
HUGO:FCGR2B
References
MACROPHAGE
MAST_CELL
CASCADE:FCGR2B
PMID:24445665
The activation of macrophages by immune complexes is determined by the balance between the triggering of activating ITAM-bearing Fc??Rs and the triggering of inhibitory ITIM-bearing Fc??RIIB.
PMID:18759918, PMID:8805703, PMID:1238444
Inhibitory signalling by Fc(gamma)RIIB does not require the SH2-domain-containing protein tyrosine phosphatase, SHP-1, in mast cells and results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase, SHIP, to the tyrosine-phosphorylated 13-amino-acid inhibitory motif of Fc(gamma)RIIB in both B cells and mast cells. SHIP, by hydrolysing the 5-phosphate of phosphatidylinositol(3,4,5)P3 and inositol(1,3,4,5)P4, suggests a mechanism by which Fc(gamma)RIIB can inhibit calcium influx and downstream responses triggered by immune receptors.
PMID:1238444
FcgammaRIIa-mediated phagocytosis was significantly enhanced in THP-1 cells overexpressing dominant-negative form of SHIP in the absence of FcgammaRII(b). These results indicate that SHIP negatively regulates FcgammaR-mediated phagocytosis through all ITAM-containing IgG receptors
PMID:12176909, PMID:12773515
In macrophages SHP-1 inhibits Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Probably downstream of FcgammaRII(b) and other receptors.