Identifiers
NAME:CD247:FCER1G:Fc_gamma_RIII*:Immunoglobulins*
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / FC_RECEPTORS
References
NATURAL_KILLER
MACROPHAGE
MAST_CELL
CASCADE:KLRB1
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
PMID:18768831
TGF-?? inhibits NK cell IFN-?? and TNF-?? production following CD16 activation.
PMID:7523143, PMID:10358164
Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72syk kinase.
PMID:8344348
CD16: zeta: gamma complex may use a ZAP-70-related non-receptor tyrosine kinase, in the CD16 signaling cascade leading to NK cell activation.
PMID:10358164
CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells.
PMID:8551221, PMID:10358164
CD16 and IL-2R Triggering Activate p21RAS in Human NK Cells via LAT/SHC/GRB2/sos pathway.
Phosphorylated Shc interacts with Grb2, which, in turn, interacts with Sos.
in_re258( Innate Immunity ):
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK
in_re160( Innate Immunity ):
PMID:20814939, PMID:12731048
Phosphorylation of the ITAM sequence in the associated partner chains induces binding and phosphorylation of tyrosine kinases Syk and ZAP70 to the ITAM downstream of NKp30 or NKp46 or NKp44