Protein Fc_gamma_RIII* map

Identifiers
HUGO:FCGR3A HUGO:FCGR3B

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MARKERS_NK  map
 Innate Immunity  map  / MARKERS_NEUTROPHIL  map
 Innate Immunity  map  / FC_RECEPTORS  map
 Innate Immunity  map  / MARKERS_MDSC  map

References
 MACROPHAGE  map
 NATURAL_KILLER  map
 MAST_CELL  map
 NEUTROPHIL  map
CASCADE:Fc_gamma_RIII
http://www.biolegend.com/cell_markers
PMID:24445665
Review
PMID:9603467
NKRP1A-induced inhibition of CD16 or p46 mediated cytolytic activity.
PMID:11449354, PMID:12393695
Fc gamma RIII alpha (CD16) autoregulates activation of downstream signals trough CD3 zeta/ Shc/ Inositol polyphosphate-5-phosphatase 145kDa ( SHIP ) pathway. The hypothetical mechanism consists of SHIP participation in inhibition of Ca('2+) -depend pathway and signal from PI3K via decreased amount IP3 [45] and PtdIns(3,4,5)P3
PMID:2139103
Fc gamma RI and Fc gamma RII on whichever cells they were expressed were capable of phagocytosing anti-Fc gamma R mAb-coated erythrocytes. Furthermore, Fc gamma RIII on mononuclear phagocytes, which appears to be a conventional integral membrane protein that spans the lipid bilayer, was capable of phagocytosing anti-Fc gamma RIII-coated erythrocytes

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_MDSC
  1. Fc_gamma_RIII*@MARKERS_MDSC map
In compartment: MARKERS_NEUTROPHIL
  1. Fc_gamma_RIII*@MARKERS_NEUTROPHIL map
In compartment: MARKERS_NK
  1. Fc_gamma_RIII*@MARKERS_NK map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD247@INNATE_IMMUNE_CELL_Cytosol map + Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  2. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. SHC1@INNATE_IMMUNE_CELL_Cytosol map → map SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map