Protein FYN map

Identifiers
HUGO:FYN
FYN oncogene related to SRC, FGR, YES
HUGO:FYN HGNC:4037 ENTREZ:2534 UNIPROT:P06241

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:21378271
PMID:19290918 PMID:9738502 PMID:12218089 PMID:10648627 PMID:27192565 PMID:22863785
 NATURAL_KILLER  map
CASCADE:NKP44
CASCADE:NKP30
CASCADE:NKP46
CASCADE:SLAMF7
CASCADE:LFA1
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:12731048, PMID:20814939
Upon engagement of activating receptors, the tyrosine-containing adapters undergo tyrosine phosphorylation mediated by Src family kinases (SFKs)??.
Cross-linking of Nkp30 or Nkp46 or NKp44 resulted in strong tyrosine phosphorylation of LCK anf FYN kinases.
PMID:10591186, PMID:24440149
Cross-Linking of LFA-1 induces tyrosine Phosphorylation of DNAM-,FYN probably phosphorylates DNAM1 Y322 in NK cells
PMID:22683124
Fyn-deficient NK cells exhibited defective killing.
PMID:19909365
FYN is adaptor protein f Fc epsilon RI signaling in mast cells

FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

References
in_re159( Innate Immunity  map ):
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. FYN@INNATE_IMMUNE_CELL_Cytosol map
  2. FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
    2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
    3. CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*:​DNAM1*|​pho|​pho@INNATE_IMMUNE_CELL_Membrane map
    4. CRKL@INNATE_IMMUNE_CELL_Cytosol map + PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
    5. SH2D1B@INNATE_IMMUNE_CELL_Membrane map + in_s1747 → map SH2D1B|​pho:​SLAMF7|​pho|​hm2@INNATE_IMMUNE_CELL_Membrane map
    6. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
    7. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane map + SLAMF7@INNATE_IMMUNE_CELL_Membrane map → map in_s5128