Complex CRKL:PI3KR(p85)* map
Complex composition:

  1. CRKL map
  2. PI3KR(p85)* map

CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:CRKL:PI3KR

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
CASCADE:NKG2D
PMID:19454690
IP of p85 indicated constitutive p85-CrkL association.
Disruption of this p85-CrkL complex would lead to impaired killing downstream of NKG2D,
probably via RAPGEF1/RAP1 pathways.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CRKL@INNATE_IMMUNE_CELL_Cytosol map + PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. BCAR1@INNATE_IMMUNE_CELL_Cytosol map + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map → map (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map