Protein SLAMF7 map

Identifiers
HUGO:SLAMF7

References
CASCADE:SLAMF7
 NATURAL_KILLER  map
INPUT_ACTIVATORS
PMID:25312647
SLAMF7 is a self-ligand; i.e., it recognizes as ligand another SLAMF7 molecule on another cell.
SLAMF7 mediates activating or inhibitory effects in NK cells, depending on whether cells express (activating) or do not express (inhibiting) the adaptor EAT-2.
SLAMF7-mediated inhibition in NK cells is accompanied by tyrosine phosphorylation of SHIP-1.
Src family kinases (fyn, probably) are responsible for SLAMF7-dependent tyrosine phosphorylation of SHIP-1.
CD45 is required for the activating function of SLAMF7 but not of 2B4 in NK cells.
PMID:16339536, PMID:17599905, PMID:25312647
SLAMF7 (CRACC) binds EAT-2,
EAT-2 mediates phosphorylation of CRACC probably via recruitment of src kynasees, probably FYN.
PMID:16339536
Ligation of CRACC induces the activation of PLC??1 and PLC??2 and PI3K signaling pathways
Ligation of CRACC induced modest tyrosine phosphorylation of the guanine nucleotide exchange factors Vav1 and the 5??? inositol phosphatase SHIP-1 and E3 ubiquitin ligase c-Cbl.
PMID:24687958
Conserved C-terminal tyrosine (Y127) is critical for activating function of human EAT-2

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. SLAMF7@INNATE_IMMUNE_CELL_Membrane map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. SH2D1B|​pho:​SLAMF7|​pho|​hm2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane map + SLAMF7@INNATE_IMMUNE_CELL_Membrane map → map in_s1747
  2. SH2D1B@INNATE_IMMUNE_CELL_Membrane map + in_s1747 → map SH2D1B|​pho:​SLAMF7|​pho|​hm2@INNATE_IMMUNE_CELL_Membrane map
  3. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane map + SLAMF7@INNATE_IMMUNE_CELL_Membrane map → map in_s5128
As Catalyser:
  1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  2. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. PLCG2@INNATE_IMMUNE_CELL_Cytosol map → map PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. PLCG1@INNATE_IMMUNE_CELL_Cytosol map → map PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map