Protein Fc_epsilon_R* map

Identifiers
HUGO:FCER1A HUGO:FCER1G HUGO:FCER2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MARKERS_MAST  map
 Innate Immunity  map  / FC_RECEPTORS  map

References
 MACROPHAGE  map
 MAST_CELL  map
CASCADE:FCER
PMID:8283051
FCE RI and FcyRlll trigger phagocytosis in mast cells
PMID:9000133
Stimulation of Fc epsilon RI results in the rapid association and activation of the Syk tyrosine kinase. Using Syk-deficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI, conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling.
PMID:1534410
Two forms of the low-affinity Fc receptor for IgE (Fc epsilon RIIa and Fc epsilon RIIb)differentially mediate endocytosis and phagocytosis
PMID:6401249
Fc receptor for IgE provides phagocytosis in macrophages.
PMID:15099567
The cross-linking of immunoglobulin E (IgE) with bivalent or multivalent
antigen results in the aggregation of FceRI, which is sufficient for initiating
down-stream signal transduction events that activate cell degranulation as well
as the de novo synthesis and secretion of lipid mediators and cytokines

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. Fc_epsilon_R*@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_MAST
  1. Fc_epsilon_R*|​pho@MARKERS_MAST map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. Fc_epsilon_R*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_epsilon_R*@INNATE_IMMUNE_CELL_Membrane map → map Fc_epsilon_R*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map