Protein NKp44* map

Identifiers
HUGO:NCR2

References
 NATURAL_KILLER  map
CASCADE:NKP44
CASCADE:IL2
PMID:23414611
NKp30 (NCR3), NKp44 (NCR2), NKp46 (NCR1) are major activating receptors in NK cells (NCRs). The efficiency of tumour cell killing by NK cells has been shown to correlate with the expression level of the NCRs.
PMID:10562324, PMID:11385609, PMID:12731048
NKp30 cooperates with NKp46 and NKp44 in the induction of NK-mediated cytotoxicity probably via the same pathways. The engagement of one NCR appears to be able to activate the signaling cascades associated with the other NCR, possibly resulting in the amplification of the activating signals.
in contrast to NKp30, the expression of NKp44 on NK cells is detected only after activation.
PMID:9625766
IL2??? ???stimulates NKp44??? ???surface expression in NK cells.
???(???NKp44???) ???that is absent in freshly isolated peripheral blood lymphocytes but is progressively expressed by all NK cells in vitro after culture in IL-2.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NKp44*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. NKp44*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
  2. DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. NKp44*@INNATE_IMMUNE_CELL_Cytosol map → map NKp44*@INNATE_IMMUNE_CELL_Membrane map
  2. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
  3. DAP12*@INNATE_IMMUNE_CELL_Membrane map + NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map