Protein DAP12* map

Identifiers
HUGO:TYROBP

References
 NATURAL_KILLER  map
CASCADE:TGFB
CASCADE:KIR2DS2
CASCADE:KIR3DS1
CASCADE:KLRC2
CASCADE:KLRC3
CASCADE:NKP44
PMID:9625766, PMID:12731048
NKp44 is coupled to the intracytoplasmic transduction machinery via the association with KARAP/DAP12.
DAP12 becomes phosphorylated after NKp44 activation.
PMID:23715743, PMID:24586048
DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors (KIR2DS4, KIR2DS, NKp44 )on natural killer cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP12*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
  2. DAP12*:​KIR2DS2@INNATE_IMMUNE_CELL_Membrane map
  3. DAP12*:​KIR3DS1@INNATE_IMMUNE_CELL_Membrane map
  4. DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
  5. DAP12*|​pho:​HLA-E:​KLRC2:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
  6. DAP12*|​pho:​HLA-E:​KLRC3:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. DAP12*:​KIR3DS1@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
  2. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
  3. DAP12*@INNATE_IMMUNE_CELL_Membrane map + NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map
  4. rDAP12*@INNATE_IMMUNE_CELL_Cytosol map → map DAP12*@INNATE_IMMUNE_CELL_Membrane map
  5. KLRC3@INNATE_IMMUNE_CELL_Membrane map + KLRD1@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​HLA-E:​KLRC3:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
  6. KLRC2@INNATE_IMMUNE_CELL_Membrane map + KLRD1@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​HLA-E:​KLRC2:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
  7. DAP12*@INNATE_IMMUNE_CELL_Membrane map + KIR3DS1@INNATE_IMMUNE_CELL_Membrane map → map DAP12*:​KIR3DS1@INNATE_IMMUNE_CELL_Membrane map
  8. KIR2DS2@INNATE_IMMUNE_CELL_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*:​KIR2DS2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. CSF2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2@default map
  3. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map