Protein KLRC2 map

Identifiers
HUGO:KLRC2

References
CASCADE:KLRC2
 NATURAL_KILLER  map
PMID:9486650, PMID:9655483, PMID:11015446
KLRC2 (D94/NKG2C), an activating NK cell receptor of the C-type lectin superfamily that binds to HLA-E, noncovalently associates with DAP12.
Activation of CD94/NKG2C/DAP12 complexes caused tyrosine phosphorylation of numerous cellular proteins, including DAP12 and Syk
CD94/NKG2C can fully activate the cell to
divide and produce cytokines, whereas NKG2D costimulates in a manner
similar to CD28 (Groh et al. 2001; Roberts et al. 2001)
The ligand of CD94/NKG2A and CD94/NKG2C receptors is the nonclassic
MHC class I molecule HLA-E (Braud et al. 1998; Llano et al. 1998)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KLRC2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP12*|​pho:​HLA-E:​KLRC2:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KLRC2@INNATE_IMMUNE_CELL_Membrane map + KLRD1@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​HLA-E:​KLRC2:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map