Protein HLA-E map

Identifiers
HUGO:HLA-E

References
CASCADE:NKG2A
 NATURAL_KILLER  map
CASCADE:KLRC2
CASCADE:KLRC3
PMID:2731048
HLA-E is a ligand of inhibitory receptor NKG2A.
PMID:9486650, PMID:9655483, PMID:11015446
KLRC2 (D94/NKG2C), an activating NK cell receptor of the C-type lectin superfamily that binds to HLA-E, noncovalently associates with DAP12.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
  2. DAP12*|​pho:​HLA-E:​KLRC2:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
  3. DAP12*|​pho:​HLA-E:​KLRC3:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KLRC3@INNATE_IMMUNE_CELL_Membrane map + KLRD1@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​HLA-E:​KLRC3:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
  2. KLRC2@INNATE_IMMUNE_CELL_Membrane map + KLRD1@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​HLA-E:​KLRC2:​KLRD1@INNATE_IMMUNE_CELL_Membrane map
  3. KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map → map HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  2. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  4. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  5. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  6. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
  7. ABL1@INNATE_IMMUNE_CELL_Cytosol map → map ABL1@INNATE_IMMUNE_CELL_Cytosol map
  8. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map