Complex HLA-E:KLRD1:NKG2A* map
Complex composition:

  1. NKG2A* map
  2. KLRD1 map
  3. HLA-E map

HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:HLA-E:KLRD1:NKG2A*

References
CASCADE:NKG2A
 NATURAL_KILLER  map
PMID:10358164
CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells.
in_re159( Innate Immunity  map ):
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.
in_re258( Innate Immunity  map ):
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map → map HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  4. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  5. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
  6. ABL1@INNATE_IMMUNE_CELL_Cytosol map → map ABL1@INNATE_IMMUNE_CELL_Cytosol map
  7. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map