Protein NKG2A* map

Identifiers
HUGO:KLRC1

References
CASCADE:NKG2A
 NATURAL_KILLER  map
PMID:12731048
Engagement of CD94/NKG2A inhibits the tyrosine phosphorylation of NCR-associated ITAM-containing polypeptides.
CD3 zeta (associated with NKp46 and NKp30) and KARAP/DAP12 (associated with NKp44).
PMID:22464172
NKG2A induces CRK phosphorylation downstream of HLA-E.
PMID:9485206
NKG2A inhibits NK cells via direct association with SHP-1 and SHP-2
PMID:10358164
CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells.
PMID:15120186
2B4 and LFA1 signalings upregulates FasL mRNA and surface expression in NK cells.
FasL transcription is inhibited by NKG2A/CD94

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
  2. HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map + HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane map → map HLA-E:​KLRD1:​NKG2A*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  4. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  5. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
  6. ABL1@INNATE_IMMUNE_CELL_Cytosol map → map ABL1@INNATE_IMMUNE_CELL_Cytosol map
  7. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map