Complex DAP12*:HLA-E:KLRC2:KLRD1
Complex composition:
- KLRD1
- HLA-E
- KLRC2
- DAP12*
DAP12*|pho:HLA-E:KLRC2:KLRD1@INNATE_IMMUNE_CELL_Membrane
Identifiers
NAME:DAP12*:HLA-E:KLRC2:KLRD1
References
CASCADE:KLRC2
NATURAL_KILLER
in_re160( Innate Immunity
):
PMID:20814939, PMID:12731048
Phosphorylation of the ITAM sequence in the associated partner chains induces binding and phosphorylation of tyrosine kinases Syk and ZAP70 to the ITAM downstream of NKp30 or NKp46 or NKp44
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- DAP12*|pho:HLA-E:KLRC2:KLRD1@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- KLRC2@INNATE_IMMUNE_CELL_Membrane
+ KLRD1@INNATE_IMMUNE_CELL_Membrane
+ HLA-E@TUMOR_CELL_AS_INDUCTOR_Membrane
+ DAP12*@INNATE_IMMUNE_CELL_Membrane
→
DAP12*|pho:HLA-E:KLRC2:KLRD1@INNATE_IMMUNE_CELL_Membrane
As Catalyser:- SYK@INNATE_IMMUNE_CELL_Cytosol
→
SYK|pho|active@INNATE_IMMUNE_CELL_Cytosol