Identifiers
secreted phosphoprotein 1
HUGO:SPP1 hgnc_id:HGNC:11255 HGNC:11255 ENTREZ:6696 UNIPROT:P10451
Sp1 transcription factor
HUGO:SP1, HGNC:11205, ENTREZ:6667, GENECARDS:GC12P053801, UNIPROT:P08047
HUGO:SP1
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / MIRNA_TF_IMMUNOSTIMULATORY
References
CASCADE:TGFB
PMID:18353785, PMID:23338822
SP1 regulates fibronectin expression downstream of TGFB signaling
PMID:23338822
collagen mRNA expression were also reduced by 48% in the transfection SP1 decoy ODN group.
Suppression of cell proliferation by Sp1 decoy ODNs
PMID:10964912
SP1 probably upregulates integrin b5 expression in fibroblasts downstream of TGFB (condurmed for osteoblastic cells only)
PMID:15001984
Smad3 complex interact with SP1 and ETS1 and induces activity of TN-C promoter.
PMID:11007770
Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor ??1 Stimulation of ??2(I)-Collagen (COL1A2) Transcription in fibroblasts
PMID:21252118
OPN promotes tumor progression via the transformation of MSC into CAF.
PMID:11013220
Cooperation and physical interaction of Smad2, Smad3, Smad4 with SP1 at the promoter of CDKN2B (p15INK4B) gene
This interaction provides a mechanism underlying the TGFB-induced growth arrest
NATURAL_KILLER
CASCADE:IL12
PMID:17705132
SP1 directly activate TBX21 (T-Bet) promoter in NK cells downstream of IL12, IL15.
Mithramycin A inhibits while monokines increase Sp1 binding to T-BET promoter and
downregulates T-BET and IFNG expression in NK cells.