Identifiers
HUGO:IFNB1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
References
NATURAL_KILLER
NEUTROPHIL
CASCADE:IFNAB
CASCADE:IL15
PMID:15289500
Lytic function by NK cells and their ability to kill MHC-negative targets was regulated by type I IFNs produced by activated DCs.
PMID:14607946
DCs activate resting NK cells by expressing MHC class I-related chain A and B (MICA/B), ligands for NKG2D, in response to IFN-alpha and IL15.
IL-15- and type I IFN-mediated induction of MICA/B in healthy donors is completely inhibited when DCs are incubated in the presence of anti-IFN-alpha/betaR or anti-IL-15Ralpha, respectively, suggesting interdependent roles of these cytokines in MICA/B expression. Indeed, DCs produced IL-15 in response to type I IFN, whereas they directly produced IFN-beta, in response to IL-15, which was followed by the production of IFN-alpha.
PMID:20237412
IFN-?? regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-??.
(STAT3 is known to be required for full activation of the Cxcr4 gene )