Identifiers
NAME:IFNAR1:IFNAR2:JAK1:TYK2
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
NATURAL_KILLER
DENDRITIC_CELL
CASCADE:IFNAB
PMID:15864272
I IFN receptor has a multichain structures, which are composed of at least two distinct subunits: IFNAR1 and IFNAR2.
IFNAR1 subunit is constitutively associated with tyrosine kinase 2 (TYK2), whereas IFNAR2 is associated with JAK1.
The initial step in both type-I- and type-II-IFN-mediated signalling is the activation of these receptor-associated JAKs
, which occurs in response to a ligand-dependent rearrangement and dimerization of the receptor subunits, followed by autophosphorylation and activation of the associated JAKs
which in turn regulate the phosphorylation and activation of STATs.
PMID:21930769, PMID:21930765, PMID:11964292, PMID:11698286, PMID:??11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II?? )
in_re707( Innate Immunity ):
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.