Protein IFNAR1 map

Identifiers
HUGO:IFNAR1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
CASCADE:IFNAB
PMID:15864272
I IFN receptor has a multichain structures, which are composed of at least two distinct subunits: IFNAR1 and IFNAR2.
IFNAR1 subunit is constitutively associated with tyrosine kinase 2 (TYK2), whereas IFNAR2 is associated with JAK1.
The initial step in both type-I- and type-II-IFN-mediated signalling is the activation of these receptor-associated JAKs
, which occurs in response to a ligand-dependent rearrangement and dimerization of the receptor subunits, followed by autophosphorylation and activation of the associated JAKs
which in turn regulate the phosphorylation and activation of STATs.
PMID:21930769, PMID:21930765
Dcs dependent tumor rejection is regulated via I IFN receptor. DCs lacking IFNAR1 display defects in antigen cross-presentation to CD8(+) T cells.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IFNAR1:​IFNAR2@INNATE_IMMUNE_CELL_Membrane map
  2. IFNAR1:​IFNAR2:​JAK1:​TYK2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IFNAR1:​IFNAR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNAR1:​IFNAR2:​JAK1:​TYK2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD83@INNATE_IMMUNE_CELL_Cytosol map → map CD83@INNATE_IMMUNE_CELL_Membrane map
  2. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL15@INNATE_IMMUNE_CELL_Cytosol map → map rIL15@INNATE_IMMUNE_CELL_Cytosol map
  4. gIL15RA@INNATE_IMMUNE_CELL_Cytosol map → map rIL15RA@INNATE_IMMUNE_CELL_Cytosol map