Identifiers
NAME:IL15:IL15RA
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
NATURAL_KILLER
DENDRITIC_CELL
CASCADE:IL15
PMID:17398124, PMID:19913445, PMID:17459805, PMID:21307131
Dendritic cells and macrophages prime natural killer cells by trans-presenting interleukin 15.
IL-15 is trans-presented on the surface of IL-15-producing cells in complex with the IL-15 receptor ?? chain (IL-15R??).
It results in tumoricidal activity of NK cells.