Protein TNIP3 map

Identifiers
HUGO:TNIP3
CASCADE:IL10

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:17485448
TNIP3 (ABIN3???) ???inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of??? ???FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream??? ???NFkB??? ???signaling??? ???downstream of IL10.
PMID:17485448, PMID:10542212
Inhibition of NfkB signaling downstream of ABIN3 inhibits expression of IL8, IL6, TNFa, IL12p40

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TNIP3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rTNIP3@INNATE_IMMUNE_CELL_Cytosol map → map TNIP3@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map + TNIP3@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL8*@INNATE_IMMUNE_CELL_Cytosol map → map rIL8*@INNATE_IMMUNE_CELL_Cytosol map
  4. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map