Protein NFKB1_p105* map

Identifiers
HUGO:NFKB1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:22435554 PMID:15169888 PMID:15485931 PMID:21217011 PMID:15199157
 MACROPHAGE  map
PMID:22435554, PMID:15169888
In unstimulated cells, TPL-2 is con???ned to a cytoplasmic complex with
the NF-jB1 precursor protein p105, and the ubiquitin-binding protein ABIN-2.
Interactions with both p105 and ABIN-2 are required to maintain
TPL-2 protein stability, while TPL-2 association with p105 also inhibits TPL-2 phosphorylation of its substrates MEK-1???2
PMID:22435554, PMID:15485931, PMID:21217011, PMID:15199157
Agonist stimulation induces IKK2, a catalytic subunit of the IKK complex, to phosphorylate p105. These phosphorylations
create a binding site for the ubiquitin E3 ligase complex SCF-bTrCP which catalyzes K48-linked polyubiquitination of p105, followed by its proteasomal
degradatio. This releases TPL-2 from p105 inhibition and allows TPL-2 to access its substrate MEK ()

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NFKB1_p105*@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p105*@INNATE_IMMUNE_CELL_Cytosol map + MAP3K8@INNATE_IMMUNE_CELL_Cytosol map + TNIP2@INNATE_IMMUNE_CELL_Cytosol map → map MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map
  2. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol map + MAP3K8@INNATE_IMMUNE_CELL_Cytosol map + TNIP2@INNATE_IMMUNE_CELL_Cytosol map
  3. NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  4. NFKB1_p105*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: