Protein MAP3K8 map

Identifiers
HUGO:MAP3K8

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 MACROPHAGE  map
PMID:22435554
immunoprecipitated MAP3K8 TPL-2 could directly phosphorylate and activate both MEK-1 and MKK4
(also known as SEK-1) in vitro. TPL-2
expression is essential for LPS activation of MEK-1???2 and
ERK-1???2 in macrophages
PMID:22435554, PMID:15169888
In unstimulated cells, TPL-2 is con???ned to a cytoplasmic complex with
the NF-jB1 precursor protein p105, and the ubiquitin-binding protein ABIN-2.
Interactions with both p105 and ABIN-2 are required to maintain
TPL-2 protein stability, while TPL-2 association with p105 also inhibits TPL-2 phosphorylation of its substrates MEK-1???2

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MAP3K8@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p105*@INNATE_IMMUNE_CELL_Cytosol map + MAP3K8@INNATE_IMMUNE_CELL_Cytosol map + TNIP2@INNATE_IMMUNE_CELL_Cytosol map → map MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map
  2. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol map + MAP3K8@INNATE_IMMUNE_CELL_Cytosol map + TNIP2@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. MEK*@INNATE_IMMUNE_CELL_Cytosol map → map MEK*|​pho@INNATE_IMMUNE_CELL_Cytosol map