Identifiers
HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 GENECARDS:MAP2K2
mitogen-activated protein kinase kinase 1
PRKMK1
HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750
mitogen-activated protein kinase kinase 2
PRKMK2
HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:24027568 PMID:9510155 PMID:14764585 PMID:15735649
REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1
REACTOME:59505 KEGG:5605 ATLASONC:GC_MAP2K2 WIKI:MAP2K2
NATURAL_KILLER
CASCADE:NKP46
CASCADE:Fc_gamma_RIII
CASCADE:TLR2_4
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK??/ERK pathway, probably throught SYK
PMID:17395718, PMID:11062502, PMID:??15536084
PAK1 activates classical MEK/ERK cascad resulted in granule movement and polarization and tumor cel lysis downstream of Nkp30, Syk and PI3K.
PMID:10843677
IL2 activates MEK (MKK)/ERK pathway in NK cells.
MKK/ERK pathway is necessary for IL-2 to activate NK cells to express at least four known biological responses: LAK generation, IFN-gamma secretion, and CD25 and CD69 expression.
PMID:11034387
MAPK activation in NK cells resulted in lysis is Ras-independent.
PMID:22435554, PMID:15169888
In unstimulated cells, TPL-2 is con???ned to a cytoplasmic complex with
the NF-jB1 precursor protein p105, and the ubiquitin-binding protein ABIN-2.
Interactions with both p105 and ABIN-2 are required to maintain
TPL-2 protein stability, while TPL-2 association with p105 also inhibits TPL-2 phosphorylation of its substrates MEK-1???2
In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1).
MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell.
MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes)
PMID:19565474 PMID:17178906 PMID:15547943