Protein IKBKG map

Identifiers
HUGO:IKBKG
inhibitor of nuclear factor kappa B kinase subunit gamma
HUGO:IKBKG hgnc_id:HGNC:5961 HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map
 Regulated Cell Death  map  / ER_STRESS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:12133805
PMID:20138012
To determine whether the tumor-promoting activity of the fibroblasts was dependent on NF-??B, we knocked down Ikk?? in CAFs using shRNA (Figure 5C). Knockdown of IKK?? did not have an effect in vitro on CAF survival (data not shown). IKK??-shRNA CAFs were then coinjected orthotopically with PDSC5 cells. Tumors coinjected with shRNA IKK?? fibroblasts grew significantly slower than did tumors coinjected with control fibroblasts
PMID:23430059
NEMO
PMID:17485448
TNIP3 (ABIN3???) ???inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of??? ???FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream??? ???NFkB??? ???signaling??? ???downstream of IL10.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  3. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map + TNIP3@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL8*@INNATE_IMMUNE_CELL_Cytosol map → map rIL8*@INNATE_IMMUNE_CELL_Cytosol map
  4. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  7. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map → map IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
  8. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  9. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol map + MAP3K8@INNATE_IMMUNE_CELL_Cytosol map + TNIP2@INNATE_IMMUNE_CELL_Cytosol map