IKK_alpha

Protein IKK_alpha_*

Identifiers
HUGO:CHUK
conserved helix-loop-helix ubiquitous kinase
HUGO:CHUK hgnc_id:HGNC:1974 HGNC:1974 ENTREZ:1147 UNIPROT:O15111

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS

References
PMID:12133805
NFkB downstream of CD28
PMID:16970925
The alternative NF-kappaB pathway induces p100 processing and p52 generation through the activation of at least two kinases, which are NIK and IKKalpha.
PMID:15536066
TCR/CD28 costimulation induces IkappaBalpha, IkappaBbeta, and IkappaBepsilon degradation, and PKC is required for IkappaBalpha and IkappaBepsilon but not IkappaBbeta degradation. PKC acts solely within the canonical pathway to activate NF-kappaB, and PKC deficiency impacts upon p100/p52 processing in a manner that is independent of NF-kappaB-induced kinase.
PMID:20138012
To determine whether the tumor-promoting activity of the fibroblasts was dependent on NF-??B, we knocked down Ikk?? in CAFs using shRNA (Figure 5C). Knockdown of IKK?? did not have an effect in vitro on CAF survival (data not shown). IKK??-shRNA CAFs were then coinjected orthotopically with PDSC5 cells. Tumors coinjected with shRNA IKK?? fibroblasts grew significantly slower than did tumors coinjected with control fibroblasts
PMID:17485448
TNIP3 (ABIN3???) ???inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of??? ???FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream??? ???NFkB??? ???signaling??? ???downstream of IL10.
PMID:17237376, PMID:21807870
Alternative pathways involeved IKKa activation by NIK. This signaling is important for DC maturation and T-cell activation (). NIK signaling is required in DCs to deliver co-stimulatory signals to CD4+??T cells
PMID:23086447
Alternative NFkB pathway induces via phosphorylation of I??B-specific kinase ?? (IKK-??) the cleavage of p100-RelB to p52-RelB, which then translocates as heterodimer into the nucleus.
Both complete p100 degradation and p100 processing to p52 may occur in Dcs and expression of IKKa, the kinase determining the activity of noncanonical NF-??B pathway, gradually increased during DC differentiation with concomitant p100 processing to p52??
PMID:2649237
In macrophages RELB??/p52 pathway is associated with M1 polarization
PMID:23422957
IKKa could regulate IRF3 activity and IRF3-dependent IFN?? and IL-12 production by DC. TAK1 (MAP3K7)-mediated IKK??/?? activation is required for IRF3-dependent IFN?? expression in DC. At the same time IKK?? regulates IRF3-mediated transcription downstream of IKK??/TBK1mediated IRF3 phosphorylation. IKKa increases the association of IRF3 with the transcriptional co-activator CBP. The increased recruitment of CBP after overexpression of IKK?? was also associated with increased transcription of endogenous IFN?? mRNA.
PMID:17254973
NfkB heterodiners could be also bloked by p52 precursor, protein p100. Dissosiation of p100 from the comprex reactivate NF-kB signaling
NIK and IKK1 regulates the degradation of nfkb2 p100 to effect NF-??B/RelA activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

IKK_alpha_*|hm2@INNATE_IMMUNE_CELL_Cytosol
IKK_alpha_*|pho|hm2|active@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: