Protein CREBBP map

Identifiers
HUGO:CREBBP
CREB binding protein
HUGO:CREBBP hgnc_id:HGNC:2348 HGNC:2348 ENTREZ:1387 UNIPROT:Q92793

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSTIMULATORY  map

References
CASCADE:TGFB
PMID:15265520
The role for CREB binding protein (CBP) and p300 as essential coactivators for SMAD-driven gene expression has been well documented and competition for p300/CBP has been suggested to mediate some examples of signal-induced transcriptional repression.
 DENDRITIC_CELL  map
PMID:23422957
IKKa could regulate IRF3 activity and IRF3-dependent IFN?? and IL-12 production by DC. TAK1 (MAP3K7)-mediated IKK??/?? activation is required for IRF3-dependent IFN?? expression in DC. At the same time IKK?? regulates IRF3-mediated transcription downstream of IKK??/TBK1mediated IRF3 phosphorylation. IKKa increases the association of IRF3 with the transcriptional co-activator CBP. The increased recruitment of CBP after overexpression of IKK?? was also associated with increased transcription of endogenous IFN?? mRNA.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CREBBP@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CREBBP:​IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CREBBP@INNATE_IMMUNE_CELL_Cytosol map + IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map → map CREBBP:​IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map → map rINFB*@INNATE_IMMUNE_CELL_Cytosol map