Protein p100 map

Identifiers
HUGO:NFKB2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 DENDRITIC_CELL  map
PMID:23086447
Alternative NFkB pathway induces via phosphorylation of I??B-specific kinase ?? (IKK-??) the cleavage of p100-RelB to p52-RelB, which then translocates as heterodimer into the nucleus.
Both complete p100 degradation and p100 processing to p52 may occur in Dcs and expression of IKKa, the kinase determining the activity of noncanonical NF-??B pathway, gradually increased during DC differentiation with concomitant p100 processing to p52??
PMID:2649237
In macrophages RELB??/p52 pathway is associated with M1 polarization ()

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. p100@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RELB:​p100@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map
  3. CD247:​NFKB1_p50*:​p100@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. RELB:​p100@INNATE_IMMUNE_CELL_Cytosol map → map RELB:​p52@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
  3. CD247:​NFKB1_p50*:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: