IKK_beta

Protein IKK_beta_*

Identifiers
HUGO:IKBKB
inhibitor of nuclear factor kappa B kinase subunit beta
HUGO:IKBKB hgnc_id:HGNC:5960 HGNC:5960 ENTREZ:3551 UNIPROT:O14920
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920
HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 GENECARDS:IKBKB REACTOME:57216 KEGG:3551 ATLASONC:GC_IKBKB WIKI:IKBKB

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / TNF_RESPONSE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR

References
PMID:12133805
PMID:16818229
IKK2 (IKBKB) phoshorylates BCL10 downstream of TCR.
Mutation of the IKKbeta phosphorylation sites on Bcl10 enhances expression of NF-kappaB target genes IL-2 and TNFalpha after activation of primary T cells.
PMID:17363905
PKC-?? regulates TGF-?????activated kinase 1 (TAK1), a member of the MAPKK kinase family, leading to activation (phosphorylation)of IKK and NF-??B in a CARMA1-independent manner in the TCR pathway
PMID:20138012
To determine whether the tumor-promoting activity of the fibroblasts was dependent on NF-??B, we knocked down Ikk?? in CAFs using shRNA (Figure 5C). Knockdown of IKK?? did not have an effect in vitro on CAF survival (data not shown). IKK??-shRNA CAFs were then coinjected orthotopically with PDSC5 cells. Tumors coinjected with shRNA IKK?? fibroblasts grew significantly slower than did tumors coinjected with control fibroblasts
PMID:28462531
PMID:17485448
TNIP3 (ABIN3???) ???inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of??? ???FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream??? ???NFkB??? ???signaling??? ???downstream of IL10.
PMID:22435554, PMID:15485931, PMID:21217011, PMID:15199157
Agonist stimulation induces IKK2, a catalytic subunit of the IKK complex, to phosphorylate p105. These phosphorylations
create a binding site for the ubiquitin E3 ligase complex SCF-bTrCP which catalyzes K48-linked polyubiquitination of p105, followed by its proteasomal
degradatio. This releases TPL-2 from p105 inhibition and allows TPL-2 to access its substrate MEK
PMID:20300203
PMID:17693255
PMID:18716620

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: