Identifiers
HUGO:REL
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:8383323 PMID:10221648 PMID:15079071
DENDRITIC_CELL
CASCADE:VEGFA
PMID:2308644
Relb transcripts were reduced by ~40% in Rel???/??? relative to wild-type BMDC
Quantitative RT-PCR validated the requirements of RelB and c-Rel in activating Cxcl2, Cd40 and Il1b gene expression
PMID:25305492
p19 and p40 subunits of IL-23, a c-Rel-dependent cytokine, was enhanced in p100-deficient cells, although expression of a RelA-dependent cytokine, TNF-??, was reduced. Nuclear translocation of c-Rel was enhanced in p100-deficient cells. p100, and not the processed p52 form, associated with c-Rel in the steady state and dissociated immediately after lipopolysaccharide stimulation in wild-type dendritic cells. Four hours after the stimulation, p100 was newly synthesized and associated with c-Rel again. In cells expressing both c-Rel and RelA, c-Rel is preferentially suppressed by p100.
→ cREL*@INNATE_IMMUNE_CELL_Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol
+ cREL*@INNATE_IMMUNE_CELL_Cytosol + IkB*@INNATE_IMMUNE_CELL_Cytosol → IkB*:NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol