Catalysis

1. IRF1@INNATE_IMMUNE_CELL_Cytosol
2. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
3. NFkB*@INNATE_IMMUNE_CELL_Cytosol

Inhibition

1. MIF@default
2. HMOX1@INNATE_IMMUNE_CELL_Cytosol
3. HDAC3:​NCOR1:​PPARG:​SUMO*:​TBL1X:​TBL1XR1@INNATE_IMMUNE_CELL_Cytosol
4. SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol
5. SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol

References
PMID:11875494
HMOX1 (HO1) mediates the inhibitory effect of IL10
on LPS-induced NOS2 (INOS) expression.
PMID:6357187, PMID:8871614
IL13 downregulates INOS activity via ILRA1/STAT6 pathway.
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and
transrepresses NF-kB dependent expression NOS2, Ccl3, Ccl7, Cxcl10.
PMID:15644117, PMID:17260466
HMGB1 induces NO production probably via NFkB dependent upregulation of INOS expression.
PMID:17689680
STAT1 binds to INOS promoter and induces INOS expression and NO production downstream of IFNG in murine macrophages. Acetylation inhibits STAT1 binding to promotor.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:23390297
MIF inhitits expression of M1 markers such as NOS2 (INOS).
PMID;PMID:20194441
HIF1 upregulates expression of INOS.