Complex SMAD3:SMAD4 map
Complex composition:

  1. SMAD4 map
  2. SMAD3 map

SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:SMAD3:SMAD4

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:TGFB
PMID:11792802, PMID:12809600
The canonical TGFB signalling pathway involves phosphorylation of the carboxy-terminal serine residue of the internal modulator SMAD proteins, SMAD2 or SMAD3, by the activated receptors. This phosphorylation induces oligomerization of SMAD2 or SMAD3 with SMAD4, which is necessary for nuclear translocatio
in_re471( Innate Immunity  map ):
PMID:12193690
Up-regulation of IL4RA by IL10 correlates with increased
IL4-dependent expression of arginase-1 (ARG1).
PMID:10925299, PMID:6357187
IL-13 induces de novo synthesis of arginase I mRNA and protein. Probably via STAT6.
PMID:23390297
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD23.
in_re485( Innate Immunity  map ):
PMID:11875494
HMOX1 (HO1) mediates the inhibitory effect of IL10
on LPS-induced NOS2 (INOS) expression.
PMID:6357187, PMID:8871614
IL13 downregulates INOS activity via ILRA1/STAT6 pathway.
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and
transrepresses NF-kB dependent expression NOS2, Ccl3, Ccl7, Cxcl10.
PMID:15644117, PMID:17260466
HMGB1 induces NO production probably via NFkB dependent upregulation of INOS expression.
PMID:17689680
STAT1 binds to INOS promoter and induces INOS expression and NO production downstream of IFNG in murine macrophages. Acetylation inhibits STAT1 binding to promotor.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
MIF inhitits expression of M1 markers such as NOS2 (INOS).
PMID;PMID:20194441
HIF1 upregulates expression of INOS.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol map + SMAD4@INNATE_IMMUNE_CELL_Cytosol map → map SMAD3|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
  4. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  5. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  6. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map