Identifiers
heme oxygenase (decycling) 1
HUGO:HMOX1 HGNC:5013 ENTREZ:3162 UNIPROT:P09601
HUGO:HMOX1
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
References
PMID:11875494
IL10 stimulates HMOX1 (HO1) expression via MAPK p38 stimulation.
IL-10-mediated increase in HMOX1 mRNA level was completely
blocked by SB203580, a specific inhibitor of p38. HMOX1
mediates IL-10-induced suppression of TNF production, and MMP9 and INOS expression.
References
in_re485( Innate Immunity ):
PMID:11875494
HMOX1 (HO1) mediates the inhibitory effect of IL10
on LPS-induced NOS2 (INOS) expression.
PMID:6357187, PMID:8871614
IL13 downregulates INOS activity via ILRA1/STAT6 pathway.
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and
transrepresses NF-kB dependent expression NOS2, Ccl3, Ccl7, Cxcl10.
PMID:15644117, PMID:17260466
HMGB1 induces NO production probably via NFkB dependent upregulation of INOS expression.
PMID:17689680
STAT1 binds to INOS promoter and induces INOS expression and NO production downstream of IFNG in murine macrophages. Acetylation inhibits STAT1 binding to promotor.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:23390297
MIF inhitits expression of M1 markers such as NOS2 (INOS).
PMID;PMID:20194441
HIF1 upregulates expression of INOS.
in_re629( Innate Immunity ):
HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.