Identifiers
HUGO:MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
HUGO:MMP9, HGNC:7176, ENTREZ:4318, GENECARDS:GC20P044637??
CLG4B "matrix metalloproteinase 9 (gelatinase B 92kD gelatinase 92kD type IV collagenase)" "matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase)"
HUGO:MMP9 HGNC:7176 ENTREZ:4318 UNIPROT:P14780 GENECARDS:MMP9 REACTOME:59395 KEGG:4318 ATLASONC:MMP9ID41408ch20q11 WIKI:MMP9
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MATRIX_REGULATION
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
Innate Immunity / TUMOR_GROWTH
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
PMID:19847259
In fibroblasts PTEN inhibit ETS2 expression; and AKT and JNK induce phosphorylqtion of ETS2. MMP9 and CCL3 are the direct targets of this transcription factor.
PMID:22179046
MiR-320 is a Pten target in fibroblasts that suppresses tumor growth
Ets2 is a direct target of miR-320 in fibroblasts
Mmp9 and Emilin2 are directly regulated by miR-320 via their 3??? UTR target sequences
PMID:11875494
MMPs plays important in the degradation and remodeling of the
extracellular matrix at sites of inflammation. HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:18776941
Expression of VEGF and bFGF, but also IL-1??, MMP9, CCL2, and CXCL2 is STAT3-dependent in myeloid cells.
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
IRF-8 and IRF-1 are the target genes in activated macrophages.
The expression levels of CXCL16, H28, IL-17R, LIF, MAP4K4, MMP9, MYC, PCDH7, PML, and SOCS7 were signi???cantly increased in macrophages
extracted form WT mice (black columns) following activation
for 4 h with IFNG and LPS. However, no changes in the expression of these genes were observed in cells extracted from IRF-8,
as well as from IRF-1 null mice.
PMID:20237412
IFN-?? regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-??.
(STAT3 is known to be required for full activation of the Cxcr4 gene )
References
in_re629( Innate Immunity ):
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.