CD74:MHC_class

Complex CD74:MHC_class_II*

Complex composition:

CD74:MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Identifiers
NAME:CD74:MHC_class_II*

References
DENDRITIC_CELL
PMID:16286017
cathepsin S activity was responsible for the IL-6-mediated decrease in MHCII ???? dimer, Ii, and H2-DM levels in DCs.
PMID:22076556
The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway. The invariant chain also facilitates MHC class II's export from the ER in a vesicle. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. This fuses with a late endosome containing the endocytosed, degraded proteins. It is then cleaved by cathepsin S (cathepsin L in cortical thymic epithelial cells), leaving only a small fragment called CLIP which blocks peptide binding until HLA-DM binds to MHC II, releasing CLIP and allowing other peptides to bind. The stable MHC class-II is then presented on the cell surface.

CD74:MHC_class_II*@Endoplasmic Reticulum_Membrane

Identifiers
NAME:CD74:MHC_class_II*

References
DENDRITIC_CELL
PMID:22076556
The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway. The invariant chain also facilitates MHC class II's export from the ER in a vesicle. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. This fuses with a late endosome containing the endocytosed, degraded proteins. It is then cleaved by cathepsin S (cathepsin L in cortical thymic epithelial cells), leaving only a small fragment called CLIP which blocks peptide binding until HLA-DM binds to MHC II, releasing CLIP and allowing other peptides to bind. The stable MHC class-II is then presented on the cell surface.

CD74:MHC_class_II*@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:CD74:MHC_class_II*

References
DENDRITIC_CELL
CASCADE:TLR2_4
CASCADE:FLT3LG
CASCADE:TNF
CASCADE:IFNAB
PMID:22076556
The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway. The invariant chain also facilitates MHC class II's export from the ER in a vesicle. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. This fuses with a late endosome containing the endocytosed, degraded proteins. It is then cleaved by cathepsin S (cathepsin L in cortical thymic epithelial cells), leaving only a small fragment called CLIP which blocks peptide binding until HLA-DM binds to MHC II, releasing CLIP and allowing other peptides to bind. The stable MHC class-II is then presented on the cell surface.
PMID:15644117
HMGB1 upregulates the expression of MHC class II molecules on the surface of macrophages and increases intigen presentation
PMID:10477595, PMID:8920882, PMID:25215878
FLT3L induces Ag-presenting ability of Dcs. Probably via induction of surface expression of class II MHC and CD86 ()

Modifications:
Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane

CD74:MHC_class_II*@Endoplasmic Reticulum_Membrane

In compartment: INNATE_IMMUNE_CELL_Membrane

CD74:MHC_class_II*@INNATE_IMMUNE_CELL_Membrane

In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

CD74:MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: