Identifiers
CD74 molecule
HUGO:CD74 hgnc_id:HGNC:1697 HGNC:1697 ENTREZ:972 UNIPROT:P04233
HUGO:CD74

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / GROWTH_FACTORS_SIGNALING_PATHWAYS 
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 

References
CASCADE:MIF
PMID:12782713
MIF signal transduction initiated by binding to CD74.
CD74 Mediates MIF Induction of ERK-1/2 Phosphorylation, PGE2 Production, and Proliferation.
 DENDRITIC_CELL 
PMID:16181339
Processing of CD74 includes its initial cleavage by Legumain, followed by late stage cleavage by Cathepsin S and Cathepsin L

1. CD74@Endoplasmic Reticulum_Membrane

1. CD74@INNATE_IMMUNE_CELL_Membrane

1. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane

1. CD74:​MIF@INNATE_IMMUNE_CELL_Membrane
2. CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane

1. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

1. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane → degraded
2. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane → CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
3. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane → CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
4. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane → CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane
5. CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane → CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
6. CD74@Endoplasmic Reticulum_Membrane + MHC_class_II*@Endoplasmic Reticulum_Membrane → CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane
7. MIF@default + CD74@INNATE_IMMUNE_CELL_Membrane → CD74:​MIF@INNATE_IMMUNE_CELL_Membrane

1. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol → ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol
2. PGE2@INNATE_IMMUNE_CELL_Cytosol → PGE2@default