MHC_class

Protein MHC_class_II*

Identifiers
HUGO:HLA-DMA HUGO:HLA-DMB HUGO:HLA-DOA HUGO:HLA-DOB HUGO:HLA-DPA1 HUGO:HLA-DPB1 HUGO:HLA-DQA1 HUGO:HLA-DQA2 HUGO:HLA-DQB1 HUGO:HLA-DQB2 HUGO:HLA-DRA HUGO:HLA-DRB1 HUGO:HLA-DRB3 HUGO:HLA-DRB4 HUGO:HLA-DRB5

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / SMAC
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION

References
PMID:12391186
Maturation of monocyte-derived DCs was induced by TNF-??
The surface levels of MHC class II increased markedly after TNF-?? stimulation on CD83+ DC
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:22076556, PMID:22076556, PMID:25720354
Like MHC class I molecules, class II molecules are also heterodimers, but in this case consist of two homogenous peptides, an ?? and ?? chain, both of which are encoded in the MHC.
MHC class II molecules present antigen peptides to CD4+ T cells
PMID:22076556, PMID:21220452
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
PMID:11702064
IL15 signaling upregulates surface expression of MHC class II
PMID:16286017
cathepsin S activity was responsible for the IL-6-mediated decrease in MHCII ???? dimer, Ii, and H2-DM levels in DCs.
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II?? )
PMID:26405600
CAFs express MHC class II but do not provide costimulation through CD80 as normal fibroblasts

MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

References
in_re25( Innate Immunity ):
PMID:22076556
The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway. The invariant chain also facilitates MHC class II's export from the ER in a vesicle. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. This fuses with a late endosome containing the endocytosed, degraded proteins. It is then cleaved by cathepsin S (cathepsin L in cortical thymic epithelial cells), leaving only a small fragment called CLIP which blocks peptide binding until HLA-DM binds to MHC II, releasing CLIP and allowing other peptides to bind. The stable MHC class-II is then presented on the cell surface.

Modifications:
In compartment: Endoplasmic Reticulum_Membrane

MHC_class_II*@Endoplasmic Reticulum_Membrane

In compartment: INNATE_IMMUNE_CELL_Cytosol

MHC_class_II*@INNATE_IMMUNE_CELL_Cytosol

In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane

CD74:MHC_class_II*@Endoplasmic Reticulum_Membrane

In compartment: INNATE_IMMUNE_CELL_Cytosol

MHC_class_II*|ubi:Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol

In compartment: INNATE_IMMUNE_CELL_Membrane

In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: